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Bağdat Caddesi, Rüzgar Gülü Çıkmazı Sokak No: 2/1 Feneryolu, Kadiköy - İstanbul

Analysis of von Willebrand Multimers

About Analysis of von Willebrand Multimers

Von Willebrand disease (vWD) is a genetic disorder caused by the absence or abnormality of the von Willebrand factor (vWF). Because von Willebrand disease is a complex condition, its diagnosis requires a broad panel of tests to ensure accurate identification and classification. Multimer analysis is an integral part of the diagnostic process and provides essential information to physicians for optimal patient management.

The HYDRAGEL von Willebrand MULTIMERS kit is designed to detect abnormalities in the distribution of vWF multimers associated with bleeding disorders. The test evaluates the overall distribution of various sizes of von Willebrand factor multimers in human plasma using agarose gel electrophoresis and immunofixation, performed on the semi-automated HYDRASYS 2 instrument.

HYDRAGEL von Willebrand MULTIMERS allows for the separation of small, medium, and high molecular weight multimers.

The test is performed in two steps:

  1. Sample pretreatment, followed by electrophoresis on SDS agarose gel to separate proteins based on their molecular weight.

  2. Direct immunofixation of the multimers on the gel using anti-human vWF antibodies, followed by immunoenzymatic staining to visualize the different multimers.

The HYDRASYS 2 SCAN FOCUSING semi-automated instrument performs all necessary steps to produce gels that are ready for visual and densitometric interpretation.

Plasma Samples

Excellent reproducibility
All multimer sizes
Densitometry assists in result interpretation
Patient profile overlaid with a normal control

Ready-to-use gels and reagents: 10 gels for 5 or 11 tests

  • HYDRAGEL 5 von Willebrand MULTIMERS Kit – Ref.: 4359
    To be used with Revelation Kit – Ref.: 4747

  • HYDRAGEL 11 von Willebrand MULTIMERS Kit – Ref.: 4360
    To be used with Revelation Kit – Ref.: 4747 (x2)

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