Hemoglobin electrophoresis is a well-established technique commonly used in clinical laboratories to screen for hemoglobinopathies (hemoglobin variants and thalassemias) in patient samples.

Many international organizations such as TIF(1), CDC, and APHL(2) recognize the advantages of Sebia’s capillary electrophoresis (CE) technology, including its high resolution and clear hemoglobin fraction profiles in the screening of hemoglobin disorders.

In addition to capillary electrophoresis, Sebia provides solutions based on gel separation techniques: HYDRAGEL HEMOGLOBIN(E) and HYDRAGEL ACID(E) HEMOGLOBIN(E), which, on HYDRASYS instruments, allow the separation of hemoglobins and the detection of major hemoglobin variants: S or D and C or E, through electrophoresis on alkaline agarose gels.

Acid gel electrophoresis, such as HYDRAGEL ACID(E) HEMOGLOBIN(E), should follow to confirm the identification of hemoglobin variants, mainly to differentiate hemoglobins S from D and E from C.

Gel visualization enables both qualitative and quantitative analysis (HbA and HbA2).